Possible interventional therapies in severe sepsis or septic shock.

@article{Wu2012PossibleIT,
  title={Possible interventional therapies in severe sepsis or septic shock.},
  author={C C Wu},
  journal={Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists},
  year={2012},
  volume={50 2},
  pages={74-7}
}
For many years, basic research with relatively straightforward pathophysiologic approaches has driven clinical trials using molecules that supposedly interfere positively with inflammatory processes. However, most of these trials have failed to demonstrate any outcome benefit. Indeed, we need to revisit current paradigms and to think about the possibility that outcome may be predetermined in severe sepsis or septic shock. In addition, an early diagnosis of sepsis prior to the onset of clinical… CONTINUE READING

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