Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan

  title={Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan},
  author={Tso-Jen Wang and San-Yuan Huang and Wei-Wen Lin and Hsin-Yi Lo and Pei-Lin Wu and Yu-Shan Wang and Yi-Syuan Wu and Huei-Chen Ko and Jean C. Shih and Ru-Band Lu},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},

MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder.

The possible interaction of MAOA and AL DH2 gene is associated with Antisocial ALC in Han Chinese males in Taiwan, however, the protective effects of the ALDH2*2 allele against alcoholism might disappear in subjects with ASPD and carrying MAOA-uVNTR 4-repeat allele in the Han Chinese male population.

Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese

Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism

This study suggests that neither the 5-HTTLPR gene nor the5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan’s Han Chinese population, but that the interaction between both genes may increase susceptibility to antissocial alcoholism.

The association between DRD2/ANKK1, 5‐HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan

  • Chin-Yeh WuYi-Syuan Wu R. Lu
  • Psychology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
Recruitment of antisocial non‐alcoholics from the Han Chinese population in Taiwan served as an important control group in examining Cloninger's hypothesis that type II alcoholism was associated with higher novelty seeking and less harm avoidance behaviors.

The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence.

This study suggests that the 5HT1B gene A-161T polymorphism alone is not a risk factor for increasing susceptibility to either AD or its subtypes, however, 5 HT1B genes might be one of the common genetic factors between the ANX/DEP ALC and antisocial ALC subgroups.

Specific personality traits and dopamine, serotonin genes in anxiety–depressive alcoholism among Han Chinese in Taiwan

MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence.

It is concluded that the MAOA and ALDH2 genes interact in ANX/DEP ALC.

Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co‐morbid with alcoholism

The results suggest that the DRD2/ANKK1 and ALDH2 genes interacted in the antisocial non‐ALC group; a connection neglected in previous studies caused by not separating antisocial ALC from ASPD.

The association between the SLC6A3 VNTR 9-repeat allele and alcoholism-a meta-analysis.

Meta-analyses suggest a possible association between the SLC6A3 VNTR A9 and alcoholic subgroup with AWS or DT, and a total of 13 research articles were included in the meta-an analyses.

Association study of the SLC6A3 VNTR (DAT) and DRD2/ANKK1 Taq1A polymorphisms with alcohol dependence in a population from northeastern Brazil.

Findings suggest that A9 allele and A9/A9 genotype of the SLC6A3 40 bp-VNTR are involved in the vulnerability to AD in the population studied, but for the DRD2/ANKK1 SNP does not present contributions to the development of AD.



Association of 5-HT1B receptor gene and antisocial behavior in alcoholism

Based on the examination of 164 alcoholic subjects, an association was found between a lower frequency of the 5-HT 1B 861C allele, antisocial personality traits and conduct disorder in alcohol-dependent subjects.

Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males.

Neither antisocial alcoholism nor antisocial personality disorder was associated with the genetic variants of MAO-A gene, either individually or for the haplotype, or for antissocial personality disorder without alcoholism.

No association between DRD2 locus and alcoholism after controlling the ADH and ALDH genotypes in Chinese Han population.

No significant association exists between the genetic variants at the DRD2 locus and alcoholism in the Chinese Han population, and several different stratifications by ADH and ALDH2 genotypes were examined.

The TaqI A1 allele of the dopamine D2 receptor gene and alcoholism in Brazil: association and interaction with stress and harm avoidance on severity prediction.

The DRD2 TaqI A1 allele showed significant interaction with stress and harm avoidance in predicting the severity of physiologic dependence, and with harm avoidance for the number of antisocial personality symptoms.

Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism.

It is concluded that the functional and structural variations in DRD2 gene do not play a major role in the development of alcoholism subtypes in a sample of alcoholics and normal controls.

Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians.

It is shown that neither alcoholism, substance use disorders nor schizophrenia show a relationship to Ser311Cys genotype, even when the 15 Cys311/Cys311 homozygous individuals are compared to others, and sib pair analysis revealed no effect of DRD2 genotype or haplotype on alcoholism or substance use disorder.

Serotonergic pathway genes and subtypes of alcoholism: association studies

The data indicate that the genes in the serotonergic pathway may be involved in the development of type II alcoholism but the gene effects are very small.