Possible increase of dopamine-beta-hydroxylase activity in the locus ceruleus of paranoid schizophrenic patients: A preliminary post-mortem study

@article{Gay1989PossibleIO,
  title={Possible increase of dopamine-beta-hydroxylase activity in the locus ceruleus of paranoid schizophrenic patients: A preliminary post-mortem study},
  author={Nadine Gay and Jean A. Cottraux and Luc Denoroy and Michel Tommasi and Nicolas Kopp},
  journal={Psychiatry Research},
  year={1989},
  volume={27},
  pages={31-38}
}
Five schizophrenic brains and seven control brains were compared for phenylethanolamine-N-methyl-transferase and dopamine-beta-hydroxylase activities. The two groups were comparable in age, sex, and post-mortem delay before autopsy. A radioenzymatic assay showed a statistically significant increase of dopamine-beta-hydroxylase activity in the rostral part of the locus ceruleus in the schizophrenic brains.