Possible implication of the effector CD4+ T-cell subpopulation TH17 in the pathogenesis of systemic scleroderma

@article{Deleuran2007PossibleIO,
  title={Possible implication of the effector CD4+ T-cell subpopulation TH17 in the pathogenesis of systemic scleroderma},
  author={Bent Deleuran and David J. Abraham},
  journal={Nature Clinical Practice Rheumatology},
  year={2007},
  volume={3},
  pages={682-683}
}
Systemic scleroderma (SSc) is one of the most severe chronic, autoimmune connective tissue diseases of unknown etiology.1 The 10-year survival rate is only 60–88%; this is even lower in specific disease subsets, such as patients with pulmonary fibrosis and pulmonary atrial hypertension.2 The main patho-anatomical feature of SSc is early vasculopathy, often associated with severe and prolonged inflammation, which leads to tissue fibrosis and atrophy. The pathology often starts in the extremities… CONTINUE READING
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