Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair.

@article{Simons1984PossibleIL,
  title={Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair.},
  author={Andreas Simons and D Tils and B von Wilcken-Bergmann and Benno M{\"u}ller-Hill},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 6},
  pages={1624-8}
}
Five DNA fragments have been cloned from yeast, chicken, and mouse DNA that titrate lac repressor in an Escherichia coli lac+ I+Z+ wild-type strain when on a multi-copy plasmid. The five repressor-binding sequences have been identified by DNA sequence determinations and DNase cleavage-inhibition patterns. They share the 14-base-pair symmetrical consensus sequence 5' T-G-T-G-A-G-C:G-C-T-C-A-C-A 3' (the colon represents the center of symmetry), which is an inverted repeat of 7 base pairs of the… CONTINUE READING

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