Possible excretion of etoposide via the intestinal mucosa

@article{Perdaems1999PossibleEO,
  title={Possible excretion of etoposide via the intestinal mucosa},
  author={Nathalie Perdaems and Nathalie Caunes and Pierre Canal and Etienne Chatelut},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1999},
  volume={43},
  pages={520-521}
}
Numerous pharmacokinetics studies of etoposide have been performed during the last decade (see Joel [1] for review). However, the respective parts played by metabolism and biliary secretion in the nonrenal elimination pathways are not yet clear. A 75-year-old woman with a pancreatic neuroendocrine carcinoma and an extrahepatic biliary obstruction was treated with cisplatin (80 mg/m given on day 1) and etoposide (100 and 50 mg given i.v. on days 1 and 2, respectively). She had a percutaneous… CONTINUE READING

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