Possible excretion of etoposide via the intestinal mucosa

  title={Possible excretion of etoposide via the intestinal mucosa},
  author={Nathalie Perdaems and Nathalie Caunes and Pierre Canal and Etienne Chatelut},
  journal={Cancer Chemotherapy and Pharmacology},
Numerous pharmacokinetics studies of etoposide have been performed during the last decade (see Joel [1] for review). However, the respective parts played by metabolism and biliary secretion in the nonrenal elimination pathways are not yet clear. A 75-year-old woman with a pancreatic neuroendocrine carcinoma and an extrahepatic biliary obstruction was treated with cisplatin (80 mg/m given on day 1) and etoposide (100 and 50 mg given i.v. on days 1 and 2, respectively). She had a percutaneous… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 12 references

The clinical pharmacology of etoposide: an update.

Cancer treatment reviews • 1996
View 3 Excerpts
Highly Influenced

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption

JW Smit, AH Schinkel, B MuÈ ller Weert, DK Meijer
Hepatology • 1998
View 1 Excerpt

Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4.

Drug metabolism and disposition: the biological fate of chemicals • 1998
View 1 Excerpt

Complete recovery of radioactivity after administration of 14C-etoposide in man (meeting abstract)

SP Joel, M Hall, RC Gaver, ML Slevin
Proc Annu Meet Am Soc Clin Oncol • 1995
View 1 Excerpt

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Proceedings of the National Academy of Sciences of the United States of America • 1987
View 1 Excerpt

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