Possible endothelial modulation of prostaglandin-stimulated renin release.

@article{Beierwaltes1990PossibleEM,
  title={Possible endothelial modulation of prostaglandin-stimulated renin release.},
  author={William H. Beierwaltes},
  journal={The American journal of physiology},
  year={1990},
  volume={258 5 Pt 2},
  pages={F1363-71}
}
Studies were run to determine whether the renal microvascular endothelium influences renin release. Blood-free rat renal cortical slices were incubated in a bicarbonate buffer for 60 min and sampled at 30 and 60 min to determine renin concentration and at 60 min for prostaglandin (PG) E2 and I2 (6-keto-PGF1 alpha) synthesis. Stimulation by 10(-6) M melittin of endogenous PGs simultaneously increased renin release, PGE2, and PGI2 synthesis, and all were inhibited by 1.6 x 10(-6) M meclofenamate… CONTINUE READING