Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy.

@article{Kinoshita1991PossibleEC,
  title={Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy.},
  author={Toshinori Kinoshita and Satoshi Hirao and Kazuya Matsumoto and Toshikazu Nakamura},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={177 1},
  pages={330-5}
}
Hepatocyte Growth Factor (HGF), which is a most potent growth factor for primary cultured hepatocytes, may act as a trigger for liver regeneration. After 70% of the rat liver was removed, HGF activity in the remnant liver began to increase within 24 h. In parallel with the activity, the HGF mRNA level in the remnant liver increased at 12 h after the operation and reached a maximum at 24 h. Increases in HGF activity and in the mRNA level were much lower and later than those in the liver of rats… CONTINUE READING