Possible effects of tetrahydrobiopterin treatment in six children with autism ‐ clinical and positron emission tomography data: a pilot study

@article{Fernell1997PossibleEO,
  title={Possible effects of tetrahydrobiopterin treatment in six children with autism ‐ clinical and positron emission tomography data: a pilot study},
  author={E. Fernell and Yasuyoshi Watanabe and Ingrid Adolfsson and Y. Tani and M. Bergstr{\"o}m and Per Hartvig and Anders Lilja and Anne‐Liis von Knorring MD. and Christopher Gillberg MD. and Bengt L{\'a}ngstr{\"o}m},
  journal={Developmental Medicine & Child Neurology},
  year={1997},
  volume={39}
}
  • E. Fernell, Yasuyoshi Watanabe, +7 authors Bengt Lángström PhD.
  • Published 1997
  • Medicine
  • Developmental Medicine & Child Neurology
  • Six children, between 3 and 5 years of age, having infantile autism according to DSM‐III‐R, were treated for 3 months with 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (R‐BH4), a cofactor for tyrosine hydroxylases in the biosynthetic pathway of catecholamines and serotonin. A criterion for inclusion in the study was a relatively low level of R‐BH4 in the cerebrospinal fluid. For clinical evaluation, the Parental Satisfaction Survey (PASS) was used every fourth week and the Griffiths Developmental… CONTINUE READING
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