Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatoid arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells.

@article{Kumagai1989PossibleDM,
  title={Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatoid arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells.},
  author={Shunichi Kumagai and Hitoshi Ishida and Kazuhiro Iwai and Takeshi Tsubata and Hisanori Umehara and Shoichi Ozaki and Takehiko Suginoshita and Shinichi Araya and Hiroo Imura},
  journal={Clinical and experimental immunology},
  year={1989},
  volume={78 3},
  pages={348-53}
}
To clarify the differential state of B cell activation in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we investigated the expression of low-affinity receptor for IgE (Fc epsilon RII; CD23) on their peripheral B cells by a cytofluorometry using H107 (CD23) and Leu-16 (CD20) monoclonal antibodies. The percentage of CD23-negative B cells in total lymphocytes was significantly greater in both groups of patients than in normal subjects, suggesting the… CONTINUE READING
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