Possible cytogenetic marker associated with myelofibrosis in chronic granulocytic leukemia and its prognostic significance.

@article{Berman1987PossibleCM,
  title={Possible cytogenetic marker associated with myelofibrosis in chronic granulocytic leukemia and its prognostic significance.},
  author={Michael Berman and William H. Knospe},
  journal={Cancer genetics and cytogenetics},
  year={1987},
  volume={25 2},
  pages={361-5}
}
An association between myelofibrosis (MF) and chronic granulocytic leukemia (CGL) has been recognized. MF is usually a sign of a poor prognosis but its relation to other important parameters of CGL is not known. We observed a 54-year-old, white male patient who was well until May 1983 when he began developing gradually increasing right hip and left shoulder pain. Clinical evaluation 3 months later revealed splenomegaly and a white blood count of 126,000 with 29 segmented neutrophils, 22 bands… CONTINUE READING

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Possible cytogenetic marker associated with myelofibrosis in chronic granulocytic leukemia and its prognostic significance .
Possible cytogenetic marker associated with myelofibrosis in chronic granulocytic leukemia and its prognostic significance .
The patient died 4 months later of intracranial hemorrhage .
The patient died 4 months later of intracranial hemorrhage .
Cytogenetic analysis by G - banding technique showed a male karyotype with all 20 bone marrow cells examined positive for the Philadelphia chromosome .
Cytogenetic analysis by G - banding technique showed a male karyotype with all 20 bone marrow cells examined positive for the Philadelphia chromosome .
An association between myelofibrosis ( MF ) and chronic granulocytic leukemia ( CGL ) has been recognized .
An association between myelofibrosis ( MF ) and chronic granulocytic leukemia ( CGL ) has been recognized .
An association between myelofibrosis ( MF ) and chronic granulocytic leukemia ( CGL ) has been recognized .
An association between myelofibrosis ( MF ) and chronic granulocytic leukemia ( CGL ) has been recognized .
An association between myelofibrosis ( MF ) and chronic granulocytic leukemia ( CGL ) has been recognized .
An association between myelofibrosis ( MF ) and chronic granulocytic leukemia ( CGL ) has been recognized .
Chromosome # 3 involvement has been reported in acute MF and essential thrombocytosis , but no specific cytogenetic abnormalities have been found in MF associated with CGL .
Chromosome # 3 involvement has been reported in acute MF and essential thrombocytosis , but no specific cytogenetic abnormalities have been found in MF associated with CGL .
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