Possible cooperation of differential adhesion and chemotaxis in mound formation of Dictyostelium.

@article{Jiang1998PossibleCO,
  title={Possible cooperation of differential adhesion and chemotaxis in mound formation of Dictyostelium.},
  author={Yi Jiang and Harold Levine and J Glazier},
  journal={Biophysical journal},
  year={1998},
  volume={75 6},
  pages={2615-25}
}
In the mound stage of Dictyostelium discoideum, pre-stalk cells sort and form a tip at the apex. How this pattern forms is as yet unknown. A cellular level model allows us to simulate both differential cell adhesion and chemotaxis, to show that with differential adhesion only, pre-stalk cells move to the surface of the mound but form no tip. With chemotaxis driven by an outgoing circular wave only, a tip forms but contains both pre-stalk and pre-spore cells. Only for a narrow range of relative… CONTINUE READING

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