Possible changes in striatal and limbic cholinergic systems in schizophrenia.

@article{Mcgeer1977PossibleCI,
  title={Possible changes in striatal and limbic cholinergic systems in schizophrenia.},
  author={P. Mcgeer and E. Mcgeer},
  journal={Archives of general psychiatry},
  year={1977},
  volume={34 11},
  pages={
          1319-23
        }
}
  • P. Mcgeer, E. Mcgeer
  • Published 1977
  • Psychology, Medicine
  • Archives of general psychiatry
  • Enzymes concerned with neurotransmitter metabolism were measured postmortem in 50 regions from the brains of 11 chronic schizophrenics, 2 patients with senile dementia, 1 depressive, and 18 controls. Enzymes studied were tyrosine hydroxylase, dopa decarboxylase, glutamic decarboxylase, choline acetyltransferase (CAT), and acetylcholinesterase. The schizophrenic group had high CAT activities in the hippocampus, caudate, putamen, and nucleus accumbens; the other patients from the same hospital… CONTINUE READING

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