Possible central role of nitric oxide in conditions clinically similar to cerebral malaria

@article{Clark1992PossibleCR,
  title={Possible central role of nitric oxide in conditions clinically similar to cerebral malaria},
  author={Ian A Clark and Katrina Rockett and William B. Cowden},
  journal={The Lancet},
  year={1992},
  volume={340},
  pages={894-896}
}
The changes in mental status during cerebral malaria, heat stroke, and recovery from major surgery are clinically similar, and are associated with high circulating concentrations of cytokines that can induce nitric oxide generation in vascular walls. This vascular nitric oxide could diffuse across the blood brain barrier, causing functional changes that include inhibition of glutamate-induced calcium entry, reduced activity of the calcium-dependent nitric oxide synthase, and thus reduced nitric… Expand
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