Possible cause of G-C-->C-G transversion mutation by guanine oxidation product, imidazolone.

@article{Kino2001PossibleCO,
  title={Possible cause of G-C-->C-G transversion mutation by guanine oxidation product, imidazolone.},
  author={Katsuhito Kino and Hiroshi Sugiyama},
  journal={Chemistry & biology},
  year={2001},
  volume={8 4},
  pages={369-78}
}
BACKGROUND The genome is constantly assaulted by oxidation reactions which are likely to be associated with oxygen metabolism, and oxidative lesions are generated by many types of oxidants. Such genotoxin-induced alterations in the genomic message have been implicated in aging and in several pathophysiological processes, particularly those associated with cancer. The guanine base (G) in genomic DNA is highly susceptible to oxidative stress due to having the lowest oxidation potential. Therefore… CONTINUE READING

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