Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population
@article{Zamani2010PossibleAO, title={Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population}, author={Mahdi Zamani and Mohammad Amin Tabatabaiefar and Solmaz Mosayyebi and Alireza Mashaghi and Parvin Mansouri}, journal={Clinical and Experimental Dermatology}, year={2010}, volume={35} }
Background. Vitiligo is an acquired idiopathic and polygenic disorder with progressive depigmentation of circumscribed patches. Its exact pathogenesis is unknown. The CD4 gene plays an important role in the cell‐mediated immune response and its association with type 1 diabetes mellitus, which is an autoimmune disease, has been previously reported.
19 Citations
An Investigation of Autoantibodies against Tyrosine Hydroxylase in Patients with Vitiligo
- Biology, Medicine
- 2012
The work in this thesis confirmed TH as an autoantigen in vitiligo, investigated the prevalence of TH antibodies and characterised several properties of TH antibody properties, including variable avidity towards their antigenic TH peptide target.
Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population
- Biology, MedicineAnnals of dermatology
- 2014
It is found that there is no association between the PTPN22 +1858 C>T gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.
Association of CD4 enhancer gene polymorphisms with rheumatoid arthritis in Egyptian female patients
- BiologyRheumatology International
- 2011
Two polymorphisms of the CD4 are associated with the susceptibility and severity of RA, and CD4-10845 genetic polymorphisms areassociated with the severity ofRA.
Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo
- BiologyBiomarker insights
- 2020
It is concluded that PTPN22 C1858T polymorphism is strongly associated with vitiligo susceptibility, however, additional studies are warranted using large number of samples from different ethnicities and geographical areas.
Impact of a CD4 gene haplotype on the immune response in minipigs
- BiologyImmunogenetics
- 2017
The genetic variability of the CD4 gene is associated with immune response-related phenotypes in MeLiM minipigs and seric IgG concentration was shown to be higher in pigs carrying the alternative haplotype at the homozygous state.
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
- BiologyAmerican journal of hematology
- 2010
The findings suggest that genetic variation in CD4 may influence susceptibility to MM, and additional studies are needed to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy.
Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.
- BiologyThe Journal of investigative dermatology
- 2011
This study re-analyzed the genome-wide data set to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data.
Contribution of HLA class II genes, DRB4*01:01, DRB1*07:01, and DQB1*03:03:2 to clinical features of Vitiligo disease in Iranian population.
- Biology, MedicineMolecular biology reports
- 2021
The findings on different subtypes of Vitiligo suggest that, despite a more apparent autoimmune involvement, a non-autoimmune nature for the etiology of VitILigo should also be considered.
Association of CD4 SNPs with fat percentage of Holstein cattle.
- Biology, MedicineGenetics and molecular research : GMR
- 2016
The results suggest that CD4 plays a role in production traits as well as in immune function, and the identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage.
References
SHOWING 1-10 OF 16 REFERENCES
Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families.
- Medicine, BiologyPigment cell research
- 2003
Genetic analysis of families with generalized vitiligo and this specific constellation of associated autoimmune disorders will be important to identify the mechanisms of genetic susceptibility to autoimmunity.
Study of the possible association of HLA class II, CD4, and CD3 polymorphisms with schizophrenia.
- Medicine, PsychologyAmerican journal of medical genetics
- 1994
Findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune-like pathogenesis in schizophrenia might exist.
Association of CD4 Enhancer Gene Polymorphisms with Rheumatoid Arthritis and Systemic Lupus Erythematosus in Taiwan
- Biology, MedicineThe Journal of Rheumatology
- 2008
The results suggest that the genetic polymorphisms at the CD4 enhancer gene are associated with the risk of development of rheumatoid arthritis and SLE and are also associated with mucosal ulcer lesions in patients with SLE.
Linkage and association of HLA class II genes with vitiligo in a Dutch population
- Medicine, BiologyThe British journal of dermatology
- 2001
Both DRB4*0101 and DQB1*0303 alleles provide significant susceptibility for vitiligo.
Clinical features and course of type A and type B vitiligo
- MedicineThe British journal of dermatology
- 1988
The hypothesis that type A and type B vitiligo have a different pathogenesis and that autoimmune mechanisms play a role only in type A is supported.
Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo
- Biology, MedicineGenes and Immunity
- 2003
It is reported here that the LMP/TAP gene region is significantly associated with vitiligo, a disorder in which biochemical defects and/or autoimmune destruction cause melanocyte loss and resulting skin depigmentation.
Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients
- Biology, MedicineDiabetes
- 1998
Several lines of evidence qualify the CD4 gene as a candidate gene in IDDM, and the aim of the present study was to investigate if theCD4*A4 allele is associated with and/or linked to IDDM in the Danish population.
CD4 T Cell-Dependent Autoimmunity against a Melanocyte Neoantigen Induces Spontaneous Vitiligo and Depends upon Fas-Fas Ligand Interactions1
- Biology, MedicineThe Journal of Immunology
- 2006
The findings show that CD4-dependent destruction of melanocytes is partially inhibited by blocking Fas-Fas ligand interactions and also highlights the importance of local control of autoimmunity, as vitiligo remains patchy and never proceeds to confluence even when Ag and autoreactive CD4+ T cells are abundant.
Decreased Total Numbers of Peripheral Blood Lymphocytes with Elevated Percentages of CD4+CD45RO+ and CD4+CD25+ of T‐Helper Cells in Non‐Segmental Vitiligo
- Medicine, BiologyThe Journal of dermatology
- 2002
In conclusion, disease‐associated, peripheral blood lymphocyte immunophenotypic profiles of vitiligo patients are consistent with the hypothesis of T cell activation as a major feature of the disorder.
Identification of a Type 1 Diabetes‐Associated CD4 Promoter Haplotype with High Constitutive Activity
- BiologyScandinavian journal of immunology
- 2004
Functional impact of a novel CD4‐181C/G SNP on stimulated CD4 promoter activity and the identification of a Novel CD4 haplotype with high constitutive promoter activity that is linked and associated with T1DM are reported.