Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population

@article{Zamani2010PossibleAO,
  title={Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population},
  author={Mahdi Zamani and Mohammad Amin Tabatabaiefar and Solmaz Mosayyebi and Alireza Mashaghi and Parvin Mansouri},
  journal={Clinical and Experimental Dermatology},
  year={2010},
  volume={35}
}
Background.  Vitiligo is an acquired idiopathic and polygenic disorder with progressive depigmentation of circumscribed patches. Its exact pathogenesis is unknown. The CD4 gene plays an important role in the cell‐mediated immune response and its association with type 1 diabetes mellitus, which is an autoimmune disease, has been previously reported. 
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Immunopathogenesis of vitiligo.
An Investigation of Autoantibodies against Tyrosine Hydroxylase in Patients with Vitiligo
TLDR
The work in this thesis confirmed TH as an autoantigen in vitiligo, investigated the prevalence of TH antibodies and characterised several properties of TH antibody properties, including variable avidity towards their antigenic TH peptide target.
Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population
TLDR
It is found that there is no association between the PTPN22 +1858 C>T gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.
Association of CD4 enhancer gene polymorphisms with rheumatoid arthritis in Egyptian female patients
TLDR
Two polymorphisms of the CD4 are associated with the susceptibility and severity of RA, and CD4-10845 genetic polymorphisms areassociated with the severity ofRA.
Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo
TLDR
It is concluded that PTPN22 C1858T polymorphism is strongly associated with vitiligo susceptibility, however, additional studies are warranted using large number of samples from different ethnicities and geographical areas.
Impact of a CD4 gene haplotype on the immune response in minipigs
TLDR
The genetic variability of the CD4 gene is associated with immune response-related phenotypes in MeLiM minipigs and seric IgG concentration was shown to be higher in pigs carrying the alternative haplotype at the homozygous state.
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
TLDR
The findings suggest that genetic variation in CD4 may influence susceptibility to MM, and additional studies are needed to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy.
Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.
TLDR
This study re-analyzed the genome-wide data set to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data.
Contribution of HLA class II genes, DRB4*01:01, DRB1*07:01, and DQB1*03:03:2 to clinical features of Vitiligo disease in Iranian population.
TLDR
The findings on different subtypes of Vitiligo suggest that, despite a more apparent autoimmune involvement, a non-autoimmune nature for the etiology of VitILigo should also be considered.
Association of CD4 SNPs with fat percentage of Holstein cattle.
TLDR
The results suggest that CD4 plays a role in production traits as well as in immune function, and the identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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