Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.

@article{Mann1997PossibleAO,
  title={Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.},
  author={J. John Mann and Kevin M. Malone and Donald A. Nielsen and David Goldman and Joseph Erdos and Joel Gelernter},
  journal={The American journal of psychiatry},
  year={1997},
  volume={154 10},
  pages={
          1451-3
        }
}
OBJECTIVE This study was designed to test the hypothesis that serotonin-system-related genes may be correlated with suicide risk. METHOD Fifty-one unrelated Caucasian inpatients with major depression, with or without a history of suicidal acts, were genotyped for a biallelic polymorphism at the tryptophan hydroxylase locus. RESULTS The less common tryptophan hydroxylase U allele occurred with greater frequency in the patients who had attempted suicide. A logistic regression analysis… CONTINUE READING

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