Possible association of a novel missense mutation A6375G in the mitochondrial cytochrome C oxidase I gene with asthenospermia in the Tunisian population.

@article{BakloutiGargouri2012PossibleAO,
  title={Possible association of a novel missense mutation A6375G in the mitochondrial cytochrome C oxidase I gene with asthenospermia in the Tunisian population.},
  author={Siwar Baklouti-Gargouri and Myriam Ghorbel and Imen Chamkha and Emna Mkaouar-Rebai and Afifa Sellami and Nozha Feki Chakroun and Faiza Fakhfakh and Leila Ammar-keskes},
  journal={Genetic testing and molecular biomarkers},
  year={2012},
  volume={16 11},
  pages={
          1298-302
        }
}
Cytochrome c oxidase encoded by multiple mitochondrial genes (COXI, COXII, and COXIII) and nuclear genes is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c. Subunits COXI and COXII of cytochrome c oxidase are known to play the most essential role in proton pumping and electron transfer. In this study we screened the somatic mitochondrial COXI gene of infertile men suffering from asthenospermia (n=34) in… CONTINUE READING

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