Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain.

@article{Kang2008PossibleAB,
  title={Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain.},
  author={Seung Gul Kang and Heon-Jeong Lee and Young-min Park and Jong Bum Choi and Changsu Han and Yong Ku Kim and Seung-Hyun Kim and Min-Soo Lee and S. I. Joe and In-Kwa Jung and Leen Kim},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2008},
  volume={32 1},
  pages={160-3}
}
Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a -2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the -2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long… CONTINUE READING

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