Possible association between autism and variants in the brain‐expressed tryptophan hydroxylase gene (TPH2)

@article{Coon2005PossibleAB,
  title={Possible association between autism and variants in the brain‐expressed tryptophan hydroxylase gene (TPH2)},
  author={H. Coon and D. Dunn and J. Lainhart and J. Miller and C. Hamil and A. Battaglia and R. Tancredi and M. Leppert and R. Weiss and W. McMahon},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2005},
  volume={135B}
}
  • H. Coon, D. Dunn, +7 authors W. McMahon
  • Published 2005
  • Biology, Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
We report a possible association between autism in our sample and a recently described brain‐expressed tryptophan hydroxylase gene (TPH2). The well‐replicated involvement of the serotonin neurotransmitter system in autism has stimulated interest in many genes in the serotonin pathway as possible candidates for mutations leading to autism susceptibility. Serotonin synthesis is controlled by the rate‐limiting enzyme tryptophan hydroxylase. A mouse study of the original tryptophan hydroxylase gene… Expand
88 Citations

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