Possible Role of Minor H Antigens in the Persistence of Donor Chimerism after Stem Cell Transplantation; Relevance for Sustained Leukemia Remission

@article{Torren2015PossibleRO,
  title={Possible Role of Minor H Antigens in the Persistence of Donor Chimerism after Stem Cell Transplantation; Relevance for Sustained Leukemia Remission},
  author={C. R. van der Torren and Y. van Hensbergen and S. Luther and Z. Aghai and Z. Rychnavska and M. Slot and S. Scherjon and N. Kr{\"o}ger and A. Ganser and E. Weissinger and E. Goulmy and L. Hambach},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
Persistent complete donor chimerism is an important clinical indicator for remissions of hematological malignancies after HLA-matched allogeneic stem cell transplantation (SCT). However, the mechanisms mediating the persistence of complete donor chimerism are poorly understood. The frequent coincidence of complete donor chimerism with graft-versus-leukemia effects and graft-versus-host disease suggests that immune responses against minor histocompatibility antigens (mHags) are playing an… Expand
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