Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats


Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats for 15 days, in the presence or absence of… (More)
DOI: 10.1155/2016/9507563


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