Possible Novel Receptor for PGD2 on Human Bronchial Epithelial Cells

  title={Possible Novel Receptor for PGD2 on Human Bronchial Epithelial Cells},
  author={T. Chiba and A. Kanda and S. Ueki and W. Ito and K. Yamaguchi and Y. Kamada and M. Takeda and T. Tanigai and H. Oyamada and H. Kayaba and J. Chihara},
  journal={International Archives of Allergy and Immunology},
  pages={23 - 27}
  • T. Chiba, A. Kanda, +8 authors J. Chihara
  • Published 2007
  • Biology, Medicine
  • International Archives of Allergy and Immunology
  • Prostaglandin D2 (PGD2), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD2 exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD2/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which… CONTINUE READING
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