Possible Involvement of Different Connexin43 Domains in Plasma Membrane Permeabilization Induced by Ischemia-Reperfusion

@article{Retamal2007PossibleIO,
  title={Possible Involvement of Different Connexin43 Domains in Plasma Membrane Permeabilization Induced by Ischemia-Reperfusion},
  author={Mauricio Antonio Retamal and Kurt Alex Schalper and Kenji F Shoji and Juan Andr{\'e}s Orellana and Michael V. L. Bennett and Juan C S{\'a}ez},
  journal={Journal of Membrane Biology},
  year={2007},
  volume={218},
  pages={49-63}
}
In vitro and in vivo studies support the involvement of connexin 43-based cell-cell channels and hemichannels in cell death propagation induced by ischemia-reperfusion. In this context, open connexin hemichannels in the plasma membrane have been proposed to act as accelerators of cell death. Progress on the mechanisms underlying the cell permeabilization induced by ischemia-reperfusion reveals the involvement of several factors leading to an augmented open probability and increased number of… CONTINUE READING
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