Possible Involvement of Ca Activated K Channels, SK Channel, in the Quercetin-Induced Vasodilatation.

@article{Nishida2009PossibleIO,
  title={Possible Involvement of Ca Activated K Channels, SK Channel, in the Quercetin-Induced Vasodilatation.},
  author={Seiichiro Nishida and Hiroyasu Satoh},
  journal={The Korean journal of physiology \& pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology},
  year={2009},
  volume={13 5},
  pages={
          361-5
        }
}
  • Seiichiro Nishida, H. Satoh
  • Published 1 October 2009
  • Biology, Medicine, Chemistry
  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca(2+) activated K(+) (K(Ca)) channel was examined. Pretreatment with NE (5 microM) or KCl (60 mM) was carried out and then, the modulation by quercetin of the constriction was examined using rat aorta ring strips (3 mm) at 36.5. Quercetin (0.1 to 100 microM) relaxed the NE-induced vasoconstrictions in a… 

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