Possible Interaction Between Topical Terbinafine and Acenocoumarol

@article{MoralesMolina2009PossibleIB,
  title={Possible Interaction Between Topical Terbinafine and Acenocoumarol},
  author={Jos{\'e} Antonio Morales-Molina and Manel Arr{\'e}bola and Pedro Acosta Robles and J. Mangana},
  journal={Annals of Pharmacotherapy},
  year={2009},
  volume={43},
  pages={1911 - 1912}
}
PossibleInteraction BetweenTopicalTerbinafmeand Acenocoumarol TO THE EDITOR: Terbinafine, an allylamine derivative, is an antifungal agent that inhibitsergosterolsynthesis,destroyingthe fungal cellular membrane. Acenocoumarol, an anticoagulant agent,hasa vitamin K antagonistic effect. Bothdrugspresent highaffinity to plasmaproteins and are metabolized by cytochromeP450isoenzymes. In addition,topical terbinafine formulations mightpresent systemicabsorption(less than 5%), and the risk of… 
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