Possible Interaction Between Topical Terbinafine and Acenocoumarol

  title={Possible Interaction Between Topical Terbinafine and Acenocoumarol},
  author={Jos{\'e} Antonio Morales-Molina and Manel Arr{\'e}bola and Pedro Acosta Robles and J. Mangana},
  journal={Annals of Pharmacotherapy},
  pages={1911 - 1912}
PossibleInteraction BetweenTopicalTerbinafmeand Acenocoumarol TO THE EDITOR: Terbinafine, an allylamine derivative, is an antifungal agent that inhibitsergosterolsynthesis,destroyingthe fungal cellular membrane. Acenocoumarol, an anticoagulant agent,hasa vitamin K antagonistic effect. Bothdrugspresent highaffinity to plasmaproteins and are metabolized by cytochromeP450isoenzymes. In addition,topical terbinafine formulations mightpresent systemicabsorption(less than 5%), and the risk of… 
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DSG may be a safe alternative to oral diclofenac when a pain reliever needs to be co-medicated with CYP2C9 substrates like warfarin antidiabetic sulfonylurea derivatives, and DDIs between topically and systemically coadministered medications are easily neglected by clinicians, which brings about potential risk of patient safety.
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Interaction between Terbinafine and Warfarin
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Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants *
A follow‐up study in a large population‐based cohort to investigate the antifungal agents that are associated with overanticoagulation during therapy with coumarins.
Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.
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Proposal for a New Tool to Evaluate Drug Interaction Cases
The Drug Interaction Probability Scale (DIPS) was developed to provide a guide to evaluating drug interaction causation in a specific patient and can serve as a guide in the preparation of articles describing case reports of drug interactions, as well as in the evaluation of published case reports.
Overan - ticoagulation associated withcombined useof antifungal agentsand coumarin anticoagulants
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  • 2002
Drugs points: serious interaction between warfarin and oral terbinafine (letter)
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  • 1998
GS.Interaction between terlJinafme andwarfarin
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  • 1998
Interaction between warfarin andoralterbinafine : manufacturer does notagree thatinteraction was with terbinafine ( letter )
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  • 1998