Possible Association Between Isotretinoin and Inflammatory Bowel Disease

  title={Possible Association Between Isotretinoin and Inflammatory Bowel Disease},
  author={D Rama Brahma Reddy and Corey A Siegel and Bruce E. Sands and Sunanda V Kane},
  journal={The American Journal of Gastroenterology},
OBJECTIVES:The Physician's Desk Reference lists inflammatory bowel disease (IBD) as a possible adverse event associated with the use of isotretinoin, a popular acne prescription medication. Our aim was to perform a systematic examination of reports of IBD associated with isotretinoin use.METHODS:All reports filed with the Food and Drug Administration (FDA) via the MedWatch system were requested and reviewed. Strength of causality was determined using the Naranjo adverse drug reaction (ADR… 

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