Possible Anandamide and Palmitoylethanolamide involvement in human stroke

@inproceedings{Naccarato2010PossibleAA,
  title={Possible Anandamide and Palmitoylethanolamide involvement in human stroke},
  author={Marcello Naccarato and Daniela Pizzuti and Stefania Petrosino and Marco Simonetto and Laura Ferigo and Fabio Chiodo Grandi and Gilberto Pizzolato and Vincenzo Di Marzo},
  booktitle={Lipids in Health and Disease},
  year={2010}
}
Endocannabinoids (eCBs) are ubiquitous lipid mediators that act on specific (CB1, CB2) and non-specific (TRPV1, PPAR) receptors. Despite many experimental animal studies proved eCB involvement in the pathogenesis of stroke, such evidence is still lacking in human patients. Our aim was to determine eCB peripheral levels in acute stroke patients and evaluate their relationship with clinical disability and stroke volume. A cohort of ten patients with a first acute (within six hours since symptoms… CONTINUE READING

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