Possibility of using mRNA expression levels for nucleic acid-metabolizing enzymes within prostate cancer cells as indices for prognostic factors.

@article{Yano2010PossibilityOU,
  title={Possibility of using mRNA expression levels for nucleic acid-metabolizing enzymes within prostate cancer cells as indices for prognostic factors.},
  author={Akira Yano and Yoshinori Shigematsu and Hiroyuki Kitano and Aki Hanayama and Akira Ozawa and Takatoshi Tacho and Motohiro Fujii},
  journal={Oncology letters},
  year={2010},
  volume={1 6},
  pages={1049-1053}
}
Thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) are enzymes involved in nucleic acid metabolism. It has been reported (based on observations of various tumor types) that the extent of the mRNA expression of these enzymes within tumor tissues may be used as a factor… CONTINUE READING