Possibility of membrane reception of neurotransmitter in sea urchin early embryos.

  • Yu. B. Shmukler
  • Published 1993 in
    Comparative biochemistry and physiology. C…


1. Methiodide derivatives of serotonin blockers--inmecarb and KYur-14 which poorly penetrate the cells specifically affect the pattern of cleavage division in half-embryos of Paracentrotus lividus and Scaphechinus mirabilis. 2. Specific [3H]8-OH-DPAT binding under conditions strictly limiting penetration of the ligand into the cells of Strongylocentrotus intermedius was also shown (Kd approximately 3 x 10(-10) M for a site with the greatest affinity). 3. On the basis of the data obtained it is concluded that neurotransmitter-specific membrane receptors may be present in sea urchin embryos during cleavage divisions. The "protosynapse" hypothesis is proposed which suggests the existence of a specific structure responsible for early blastomere interaction involving transmitters.


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@article{Shmukler1993PossibilityOM, title={Possibility of membrane reception of neurotransmitter in sea urchin early embryos.}, author={Yu. B. Shmukler}, journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology}, year={1993}, volume={106 1}, pages={269-73} }