Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.

@article{Kimura1981PossibilityOE,
  title={Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.},
  author={Motoo Kimura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 9},
  pages={5773-7}
}
  • Motoo Kimura
  • Published 1981 in
    Proceedings of the National Academy of Sciences…
The rate of evolution in terms of the number of mutant substitutions in a finite population is investigated assuming a quantitative character subject to stabilizing selection, which is known to be the most prevalent type of natural selection. It is shown that, if a large number of segregating loci (or sites) are involved, the average selection coefficient per mutant under stabilizing selection may be exceedingly small. These mutants are very slightly deleterious but nearly neutral, so that… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…