Possibility of enterohepatic recycling of ketoprofen in dogs.


Ketoprofen is mainly cleared by glucuronidation. The rate of glucuronidation of this compound has been demonstrated to be greater in dog than in human liver microsomes. Dog is the most common secondary nonprimate species used in drug metabolism studies in the pharmaceutical industry. Therefore, this study was undertaken to provide valuable information to… (More)


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@article{Granero2008PossibilityOE, title={Possibility of enterohepatic recycling of ketoprofen in dogs.}, author={G E Granero and Gordon L Amidon}, journal={International journal of pharmaceutics}, year={2008}, volume={349 1-2}, pages={166-71} }