Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity

@article{Doskali2011PossibilityOA,
  title={Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity},
  author={M. Doskali and Y. Tanaka and M. Ohira and K. Ishiyama and H. Tashiro and K. Chayama and H. Ohdan},
  journal={Journal of Immunotherapy},
  year={2011},
  volume={34},
  pages={129–138}
}
  • M. Doskali, Y. Tanaka, +4 authors H. Ohdan
  • Published 2011
  • Biology, Medicine
  • Journal of Immunotherapy
  • We recently showed that interleukin (IL)-2-stimulated CD56+ cells derived from the liver exert vigorous cytotoxicity against hepatocellular carcinoma (HCC) by their binding to the tumor necrosis factor-related apoptosis-inducing ligand expressed on natural killer cells and the corresponding death receptors, and exhibit inhibitory effects on hepatitis C virus (HCV) replication by production of a high level of interferon-&ggr;. These findings prompted us to develop a technique to increase the… CONTINUE READING
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    References

    SHOWING 1-10 OF 36 REFERENCES
    A new method for in vitro expansion of cytotoxic human CD3-CD56+ natural killer cells.
    • 120
    Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis
    • 698
    • PDF
    Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein
    • 480
    • PDF
    Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta.
    • 172
    Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions
    • 464
    • PDF
    TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors.
    • 323