Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity

@article{Doskali2011PossibilityOA,
  title={Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity},
  author={Marlen Doskali and Yuka Tanaka and Masahiro Ohira and Kohei Ishiyama and Hirotaka Tashiro and Kazuaki Chayama and Hideki Ohdan},
  journal={Journal of Immunotherapy},
  year={2011},
  volume={34},
  pages={129–138}
}
We recently showed that interleukin (IL)-2-stimulated CD56+ cells derived from the liver exert vigorous cytotoxicity against hepatocellular carcinoma (HCC) by their binding to the tumor necrosis factor-related apoptosis-inducing ligand expressed on natural killer cells and the corresponding death receptors, and exhibit inhibitory effects on hepatitis C virus (HCV) replication by production of a high level of interferon-&ggr;. These findings prompted us to develop a technique to increase the… 
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