Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity

@article{Doskali2011PossibilityOA,
  title={Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity},
  author={Marlen Doskali and Yuka Tanaka and Masahiro Ohira and Kohei Ishiyama and Hirotaka Tashiro and Kazuaki Chayama and Hideki Ohdan},
  journal={Journal of Immunotherapy},
  year={2011},
  volume={34},
  pages={129–138}
}
We recently showed that interleukin (IL)-2-stimulated CD56+ cells derived from the liver exert vigorous cytotoxicity against hepatocellular carcinoma (HCC) by their binding to the tumor necrosis factor-related apoptosis-inducing ligand expressed on natural killer cells and the corresponding death receptors, and exhibit inhibitory effects on hepatitis C virus (HCV) replication by production of a high level of interferon-&ggr;. These findings prompted us to develop a technique to increase the… 
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25 Citations
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25 Citations

Comparative analysis of T-cell depletion method for clinical immunotherapy-anti-hepatitis c effects of natural killer cells via interferon-γ production.
A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma.
TLDR
Different representation of natural T cells and NK cells in local tumor tissues and in the periphery blood of patients with HCC are described and a new type of FOXP3-expressing natural T cell spontaneously arising in the TILs of HCC is identified.
Increased numbers and functional activity of CD56+ T cells in healthy cytomegalovirus positive subjects
TLDR
Using Class I HLA pentamers, it was found that CD56+ T cells from CMV+ subjects contained similar proportions of antigen‐specific CD8 + T cells to CD56− T cells in donors of several different HLA types, which strongly implicates CD56- T cells as being an important component of the cytotoxic T‐cell response to CMV in healthy carriers.
NK Cells Prevalence, Subsets and Function in Viral Hepatitis C
Innate immunity appears to play an important role in the pathogenesis of viral hepatitis C. Among various cell subsets of this immunity natural killer (NK) cells raised particular interest. These…
Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: an in vitro proof-of-concept
TLDR
It is demonstrated that allogeneic suicide gene-modified lymphocytes (SGMLs) could potently, dose- and time-dependently, inhibit viral replication and post-transplant immunosuppression may not interfere with this adoptive cell immunotherapy approach.
Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma in nude mice
TLDR
It is concluded that IL-2 may enhance the antitumor activity of the NK cells, and thereby inhibit the metastases of hepatocellular carcinoma in mice.
Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy
TLDR
The factors needed for NK cell differentiation in vitro are reviewed, which stem cell sources have been used, published protocols, challenges and future directions for Good Manufacturing Practice protocols are reviewed.
Quantitative Effect of Natural Killer–Cell Licensing on Hepatocellular Carcinoma Recurrence after Curative Hepatectomy
Tanimine and colleagues report that multiplicity of compound KIR-HLA genotypes in blood cells of patients with hepatocellular carcinoma (HCC) correlate with HCC recurrence, supporting therapeutic…
Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients.
Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma
TLDR
This is the first-in-human immunotherapy study using deceased donor liver-derived NK cells to prevent HCC recurrence after LT, and this treatment was well tolerated and resulted in no HCCRecurrent after LT.
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