Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity
@article{Doskali2011PossibilityOA, title={Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity}, author={M. Doskali and Y. Tanaka and M. Ohira and K. Ishiyama and H. Tashiro and K. Chayama and H. Ohdan}, journal={Journal of Immunotherapy}, year={2011}, volume={34}, pages={129–138} }
We recently showed that interleukin (IL)-2-stimulated CD56+ cells derived from the liver exert vigorous cytotoxicity against hepatocellular carcinoma (HCC) by their binding to the tumor necrosis factor-related apoptosis-inducing ligand expressed on natural killer cells and the corresponding death receptors, and exhibit inhibitory effects on hepatitis C virus (HCV) replication by production of a high level of interferon-&ggr;. These findings prompted us to develop a technique to increase the… CONTINUE READING
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