Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.

@article{Wong1986PositronET,
  title={Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.},
  author={Dean F. Wong and Henry N. Jr. Wagner and Larry E. Tune and Robert F. Dannals and Godfrey D. Pearlson and Jonathan M. Links and Carol A. Tamminga and Emmanuel Broussolle and Hayden T. Ravert and A. A. Wilson and Juey Kong Toung and Jan Mal{\'a}t and J A Williams and Lorcan A. O'Tuama and Solomon H. Snyder and Michael J. Kuhar and Albert Gjedde},
  journal={Science},
  year={1986},
  volume={234 4783},
  pages={
          1558-63
        }
}
In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number of receptors is a result of adaptation to these drugs rather than a biochemical abnormality intrinsic… 

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D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride.

TLDR
The hypothesis of generally elevated central D2 dopamine receptor densities in schizophrenia was not supported by the present findings, and significantly higher densities were found in the left than in the right putamen but not in the caudate nucleus.

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Dopamine receptors and transporters in Parkinson's disease and schizophrenia

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  • 1990
TLDR
Early evidence indicating abnormal D2 structure as well as a reduced link between D1 and D2 warrant a detailed study of the genes for these two receptors in schizophrenia.

D2 Dopamine Receptor Binding in the Basal Ganglia of Antipsychotic-Free Schizophrenic Patients

TLDR
The results suggest that alterations in striatal D2 receptor distribution and density do occur in schizophrenia, and possibly reflect wider disruptions in prefrontal-striatal-limbic circuits.

No D2 receptor increase in PET study of schizophrenia.

TLDR
It is now possible to examine D2dopamine receptor binding in the brains of living human subjects by means of new brain-imaging techniques and radiolabeled receptor ligands and evidence of a slight increase in D2Dopamine receptors in a group of schizophrenic patients is reported.
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