Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.

@article{Nelson2011PositronET,
  title={Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.},
  author={Linda D. Nelson and Prabha Siddarth and Vladimir Kepe and Kevin Scheibel and S. C. Huang and Jorge R. Barrio and Gary W. Small},
  journal={Archives of neurology},
  year={2011},
  volume={68 6},
  pages={
          768-74
        }
}
OBJECTIVES To determine the neuropathological load in the living brain of nondemented adults with Down syndrome using positron emission tomography with 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) and to assess the influence of age and cognitive and behavioral functioning. For reference, [(18)F]FDDNP binding values and patterns were compared with those from patients with Alzheimer disease and cognitively intact control participants… CONTINUE READING

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