Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development

@article{Bergstrm2003PositronET,
  title={Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development},
  author={Mats Bergstr{\"o}m and Anders Grahn{\'e}n and Bengt L{\aa}ngstr{\"o}m},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={59},
  pages={357-366}
}
The realisation that new chemical entities under development as drug candidates fail in three of four cases in clinical trials, together with increased costs and increased demands of reducing preclinical animal experiments, have promoted concepts for improvement of early screening procedures in humans. Positron emission tomography (PET) is a non-invasive imaging technology, which makes it possible to determine drug distribution and concentration in vivo in man with the drug labelled with a… CONTINUE READING

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Showing 1-10 of 31 references

Palladium mediated synthesis of [carboxy-11C]amides and hydrazides using [11C] carbon monoxide

  • F Karimi, B Långström
  • J Chem Soc Perkin I
  • 2002
2 Excerpts

Palladium-mediated carboxylation of aryl halides (triflates) or benzyl halides using (13C)/ [11C] carbon monoxide with tetrabutylammonium hydroxide or trimethylphenylammonium hydroxide

  • F Karimi, B Långström
  • J Chem Soc Perkin Trans
  • 2002
2 Excerpts

11C/13C]Carbon monoxide in palladium-mediated reactions to prepare 11C-labelled imides

  • F Karimi, T Kihlberg
  • J Chem Soc Perkin Transact I
  • 2001
2 Excerpts

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