Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment

@article{Wiley2006PositronET,
  title={Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment},
  author={Clayton A Wiley and Brian J. Lopresti and James T. Becker and Fernando E. Boada and Oscar L. Lopez and John W Mellors and Carolyn C. Meltzer and Stephen R. Wisniewski and Chester A. Mathis},
  journal={Journal of NeuroVirology},
  year={2006},
  volume={12},
  pages={262-271}
}
The pathology associated with late-stage dementia in human immunodeficiency virus (HIV) infection has been studied extensively. Neuropathological examination has demonstrated abundant activation and infection of macrophages/microglia termed HIV encephalitis. For obvious reasons, less is known regarding the neuropathology of minor cognitive impairment seen in earlier stages of HIV infection. The authors examined the utility of the peripheral benzodiazepine receptor ligand PK11195 in positron… CONTINUE READING