Positron emission tomography analysis of [11C]KW-6002 binding to human and rat adenosine A2A receptors in the brain.

Abstract

Adenosine A(2A) receptors are found on striatal neurones projecting to the external pallidum. KW-6002 (istradefylline) is a potent and selective antagonist for the adenosine A(2A) receptors in the CNS and acts to inhibit the excessive activity of this pathway in the MPTP marmoset model of PD, thus relieving parkinsonism. The objectives of this study were to… (More)
DOI: 10.1002/syn.20539

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@article{Brooks2008PositronET, title={Positron emission tomography analysis of [11C]KW-6002 binding to human and rat adenosine A2A receptors in the brain.}, author={Denise Brooks and Miroslava Doder and Salih Osman and Soumya Luthra and Ella Hirani and Steve Hume and Hiroshi Kase and Judith Kilborn and S Martindill and A. Mori}, journal={Synapse}, year={2008}, volume={62 9}, pages={671-81} }