Positron emission tomographic study of central histamine H1-receptor occupancy in human subjects treated with epinastine, a second-generation antihistamine.

@article{Yanai1995PositronET,
  title={Positron emission tomographic study of central histamine H1-receptor occupancy in human subjects treated with epinastine, a second-generation antihistamine.},
  author={Kazuhiko Yanai and Jong Hoon Ryu and Takehiko Watanabe and Ren Iwata and Tatsuo Ido and Masato Asakura and Ryusei Matsumura and Masatoshi Itoh},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1995},
  volume={17 Suppl C},
  pages={
          64-9
        }
}
Histamine H1-receptor occupancy in the human brain was measured in healthy young volunteers by positron emission tomography (PET) using [11C]doxepin. d-Chlorpheniramine, a selective and classical antihistamine, occupied 76.8 +/- 4.2% of the averaged values of available histamine H1 receptors in the frontal cortex after its administration in a single oral dose of 2 mg. Epinastine, a non-sedative antihistamine, occupied 13.2 +/- 18.5% of the available H1 receptors in the human frontal cortex… CONTINUE READING

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