Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (±)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performance

@article{McCann2008PositronET,
  title={Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (±)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performance},
  author={Una D. McCann and Zsolt Szabo and Melin Vranesic and Michael R. Palermo and William B Mathews and Hayden T. Ravert and Robert F. Dannals and George A. Ricaurte},
  journal={Psychopharmacology},
  year={2008},
  volume={200},
  pages={439-450}
}
Background(±)3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is a recreational drug and brain serotonin (5-HT) neurotoxin. Under certain conditions, MDMA can also damage brain dopamine (DA) neurons, at least in rodents. Human MDMA users have been found to have reduced brain 5-HT transporter (SERT) density and cognitive deficits, although it is not known whether these are related. This study sought to determine whether MDMA users who take closely spaced sequential doses, which engender high… CONTINUE READING
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