Positron emission tomographic imaging of cardiac sympathetic innervation using 6-[18F]fluorodopamine: initial findings in humans.

@article{Goldstein1993PositronET,
  title={Positron emission tomographic imaging of cardiac sympathetic innervation using 6-[18F]fluorodopamine: initial findings in humans.},
  author={David S Goldstein and Graeme Eisenhofer and Bob Dunn and I Armando and J. W. Lenders and Ehud Grossman and Courtney Holmes and Kenneth Lee Kirk and S L Bacharach and Rob J. Adams},
  journal={Journal of the American College of Cardiology},
  year={1993},
  volume={22 7},
  pages={1961-71}
}
OBJECTIVES This study evaluated the safety, efficacy and validity of 6-[18F]fluorodopamine positron emission tomographic scanning of cardiac sympathetic innervation and function in humans. METHODS Positron emission tomography (PET) scans, arterial blood and urine were obtained after a 3-min intravenous infusion of 6-[18F]fluorodopamine (1 to 4 mCi, 188 to 809 mCi/mmol) in healthy volunteers, with or without pretreatment with oral desipramine to inhibit neuronal uptake of catecholamines… CONTINUE READING