Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings

@article{Mccann1998PositronET,
  title={Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings},
  author={U Mccann and Zsolt Szabo and Ursula A Scheffel and Rf Dannals and G Orlando Ricaurte},
  journal={The Lancet},
  year={1998},
  volume={352},
  pages={1433-1437}
}
BACKGROUND (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is a popular recreational drug that selectively damages brain serotonin (5-HT) neurons in animals at doses that closely approach those used by humans. We investigated the status of brain 5-HT neurons in MDMA users. METHODS We enrolled 14 previous users of MDMA who were currently abstaining from use and 15 controls who had never used MDMA. We used positron emission tomography (PET) with the radioligand carbon-11-labelled McN… CONTINUE READING
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