Positron emission tomographic evidence for progression of human MPTP-induced dopaminergic lesions.

@article{Vingerhoets1994PositronET,
  title={Positron emission tomographic evidence for progression of human MPTP-induced dopaminergic lesions.},
  author={François J.G. Vingerhoets and Barry J Snow and James W. Tetrud and James William Langston and Michael Schulzer and Donald B. Calne},
  journal={Annals of neurology},
  year={1994},
  volume={36 5},
  pages={765-70}
}
Transient exposure to the toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a syndrome resembling idiopathic parkinsonism (IP). While IP inevitably progresses, the long-term evolution of MPTP-parkinsonism is unknown. Fluorodopa positron emission tomography (FD-PET) is a reliable tool for assessing nigrostriatal dopaminergic function. We performed FD-PET and clinical assessments on two occasions, 7 years apart, on 10 human subjects exposed to MPTP (age at the first scan, 32.7… CONTINUE READING

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