Positron emission tomographic analysis of dose-dependent MDL 100,907 binding to 5-hydroxytryptamine-2A receptors in the human brain.

@article{Andre1998PositronET,
  title={Positron emission tomographic analysis of dose-dependent MDL 100,907 binding to 5-hydroxytryptamine-2A receptors in the human brain.},
  author={Bengt A. Andr{\'e}e and Svante Nyberg and Hiroshi Ito and Nathalie Ginovart and Friedrich Brunner and Françoise Jaquet and Christer Halldin and Lars Farde},
  journal={Journal of clinical psychopharmacology},
  year={1998},
  volume={18 4},
  pages={317-23}
}
Selective 5-hydroxytryptamine-2A (5-HT2A) antagonism has been proposed as a mechanism of atypical antipsychotic drug action. MDL 100,907, a new selective 5-HT2A receptor antagonist, has high affinity in vitro for 5-HT2A receptors and is being developed as a potential antipsychotic drug. In this study, neocortical 5-HT2A receptor occupancy was measured in six healthy male volunteers after placebo and escalating single doses (1-72 mg) of MDL 100,907 using positron emission tomography and the… CONTINUE READING
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