Positron Emission Tomography and Fluorodeoxyglucose Studies of Metabolic Hyperfrontality and Psychopathology in the Psilocybin Model of Psychosis

@article{Vollenweider1997PositronET,
  title={Positron Emission Tomography and Fluorodeoxyglucose Studies of Metabolic Hyperfrontality and Psychopathology in the Psilocybin Model of Psychosis},
  author={F Vollenweider and K. L. Leenders and Christian Scharfetter and Philip Maguire and Otto Stadelmann and Jules Angst},
  journal={Neuropsychopharmacology},
  year={1997},
  volume={16},
  pages={357-372}
}
  • F Vollenweider, K. L. Leenders, +3 authors Jules Angst
  • Published 1997
  • Psychology, Medicine
  • Neuropsychopharmacology
  • The effects of the indolehallucinogen psilocybin, a mixed 5-HT2 and 5-HT1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15- or 20-mg dose of psilocybin.Psychotomimetic doses of psilocybin were found to produce a global increase in cerebral metabolic rate of glucose (CMRglu) with significant and most marked increases in the frontomedial and frontolateral cortex (24.3%), anterior… CONTINUE READING

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