Positron Emission Tomography Studies on Binding of Central Nervous System Drugs and P-Glycoprotein Function in the Rodent Brain

@article{Elsinga2005PositronET,
  title={Positron Emission Tomography Studies on Binding of Central Nervous System Drugs and P-Glycoprotein Function in the Rodent Brain},
  author={Philip H. Elsinga and N. Harry Hendrikse and Joost Bart and Aren van Waarde and Willem Vaalburg},
  journal={Molecular Imaging and Biology},
  year={2005},
  volume={7},
  pages={37-44}
}
The permeability of the blood–brain barrier (BBB) is one of the factors determining the bioavailability of drugs in the brain. The BBB only allows passage of lipophilic drugs by passive diffusion. However, some lipophilic drugs hardly enter the brain. The transmembrane protein P-glycoprotein (P-gp) is one of the carrier systems that is responsible for transportation of drugs out of the brain. P-Glycoprotein affects the pharmacokinetics of many drugs and can be inhibited by administration of… CONTINUE READING

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