Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence

@article{Martnez2009PositronET,
  title={Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence},
  author={Diana Mart{\'i}nez and Mark Slifstein and Roberto Gil and Dah-Ren Hwang and Anissa Abi-Dargham},
  journal={Biological Psychiatry},
  year={2009},
  volume={65},
  pages={175-180}
}
BACKGROUND Rodent models as well as studies in humans have suggested alterations in serotonin (5-HT) innervation and transmission in early-onset genetically determined or type II alcoholism. This study examines two indices of serotonergic transmission, 5-HT transporter levels and 5-HT(1A) availability, in vivo, in type II alcoholism. This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A… CONTINUE READING

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