Positron Emission Tomographic Studies of the Processing of Singe Words

  title={Positron Emission Tomographic Studies of the Processing of Singe Words},
  author={Steven E. Petersen and Peter T. Fox and Michael I. Posner and Mark A. Mintun and Marcus E. Raichle},
  journal={Journal of Cognitive Neuroscience},
PET images of blood flow change that were averaged across individuals were used to identify brain areas related to lexical (single-word) processing, A small number of discrete areas were activated during several task conditions including: modality-specific (auditory or visual) areas activated by passive word input, primary motor and premotor areas during speech output, and yet further areas during tasks making semantic or intentional demands. 

Memory mechanisms in the processing of words and word-like symbols.

  • M. Raichle
  • Psychology, Biology
    Ciba Foundation symposium
  • 1991
These studies reveal the very distributed, modular nature of this implementation of mental activities in the human brain and provide some preliminary insights into the role of memory mechanisms in the process.

Language activation studies with positron emission tomography.

There is particular interest at present in the precise roles of left PSTG and DLPFC in single-word comprehension and generation, and interpretation of the results depends critically on the design of the single- word tasks used for behavioural activation.

The Neurobiological Basis of Reading

The results from studies using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) in adults have largely revealed the involvement of left-hemisphere perisylvian areas

How to select epochs of cognitive event-related potentials for brain mapping?

  • Y. AbdullaevN. I. Tsygankov
  • Psychology
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 1992

Positron emission tomographic study of the brain during involuntary syntactic processing

A positron emission tomography (PET) method was used to study the human brain for involuntary processing of syntactically organized information. Eight healthy subjects counted a certain letter in a

Regional cerebral blood flow during word and nonword reading

Examination of changes in regional cerebral blood flow using positron emission tomography during overt word and nonword reading tasks to determine structures involved in semantic processing found data are broadly consistent with brain regions generally associated with reading based on other neuropsychological paradigms.

Sentence comprehension and word repetition: a positron emission tomography investigation.

Using positron emission tomography, visual presentation of sentences was shown to cause increased regional cerebral blood flow relative to word lists in the left lateral anterior superior and middle

Event-Related Brain Potential Imaging of Semantic Encoding during Processing Single Words

The results provide the time course for parts of the circuitry involved in semantic processing of words and demonstrate how combining the spatial localization of PET with the temporal resolution of ERPs helps to understand the brain mechanisms involved in human cognition.

Automaticity and cognitive anatomy: is word recognition "automatic"?

  • T. Carr
  • Biology, Psychology
    The American journal of psychology
  • 1992
Recent progress in neural imaging technologies such as positron emission tomography and dense-array recording of event-related potentials has greatly increased the capacity for in vivo measurement of



Positron emission tomographic studies of the cortical anatomy of single-word processing

The use of positron emission tomography to measure regional changes in average blood flow during processing of individual auditory and visual words provides support for multiple, parallel routes

Localization of cognitive operations in the human brain.

Support for the general hypothesis that the human brain localizes mental operations of the kind posited by cognitive theories is integrated in the performance of cognitive tasks such as reading comes from studies in mental imagery, timing, and memory.

Functional mapping of the human cerebellum with positron emission tomography.

Alterations of local neuronal activity induced within the human cerebellum by tactile stimulation and voluntary movement were mapped with positron emission tomographic measurements of brain blood flow and permits investigation of functional-anatomical relations within thehuman cerebellar.

A Highly Accurate Method of Localizing Regions of Neuronal Activation in the Human Brain with Positron Emission Tomography

  • M. MintunP. FoxM. Raichle
  • Psychology, Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1989
The analysis technique enabling high-resolution functional brain mapping with positron emission tomography is described and simulations are presented to illustrate its advantages and limitations.

Retinotopic organization of human visual cortex mapped with positron- emission tomography

The retinotopic organization of primary visual cortex was mapped in normal human volunteers and changes in stimulus location caused systematic, highly significant changes in response locale within visual cortex.

The role of cerebral cortex in the generation of voluntary saccades: a positron emission tomographic study.

The frontal eye fields were discrete cortical regions consistently active during the generation of voluntary SEMs and uninfluenced by target presence, type of cue, or task complexity, indicating a predominantly motor function.

Regional cerebral blood flow correlates of auditory processing.

Comparison of rCBF from homologous regions of the two hemispheres confirmed a clear difference between the rhyme detection and meaning detection tasks, with the former strongly lateralized to the left hemisphere.

Serial aspects of language and speech related to prefrontal cortical activity. A selective review.

There is evidence that action programs for speech and language, like other serial programs of the CNS, are handled specifically by the prefrontal cortex, andMeasurements of regional cerebral blood flow (rCBF) and metabolic rate (rCMR) support this view.

Event-Related Potentials to Infrequent Changes in Synthesized Phonetic Stimuli

ERPs to synthetic consonantvowel syllables elicited a "mismatch negativity" as well as an enhanced N100 component of the ERP even when subjects did not pay attention to the stimuli, suggesting that in these areas there are neural networks that are automatically activated by speech-specific auditory stimulus features such as formant transitions.