Positive versus negative signaling by lymphocyte antigen receptors.

  title={Positive versus negative signaling by lymphocyte antigen receptors.},
  author={James I. Healy and Christopher C. Goodnow},
  journal={Annual review of immunology},
Antigen receptors on lymphocytes play a central role in immune regulation by transmitting signals that positively or negatively regulate lymphocyte survival, migration, growth, and differentiation. This review focuses on how opposing positive or negative cellular responses are brought about by antigen receptor signaling. Four types of extracellular inputs shape the response to antigen: (a) the concentration of antigen; (b) the avidity with which antigen is bound; (c) the timing and duration of… CONTINUE READING


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