Positive shift of Nav1.8 current inactivation curve in injured neurons causes neuropathic pain following chronic constriction injury.

Abstract

Neuropathic pain is a global medical concern, characterized by spontaneous pain, heat hyperalgesia and mechanical allodynia. The condition has been associated with alterations in the voltage‑gated sodium channels, Nav1.8 and Nav1.9, in nociceptive neurons termed nociceptors. However, an explanation for the contribution of these channels to the phenotype… (More)
DOI: 10.3892/mmr.2015.3839

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@article{Li2015PositiveSO, title={Positive shift of Nav1.8 current inactivation curve in injured neurons causes neuropathic pain following chronic constriction injury.}, author={Guixia Li and Xifang Liu and Jingnan Du and Jianzhao Chen and Fenglin She and Chun Wu and Chunli Li}, journal={Molecular medicine reports}, year={2015}, volume={12 3}, pages={3583-90} }